作者: Katherine E. Vest , Paul A. Cobine
DOI: 10.1002/9781119951438.EIBC2155
关键词:
摘要: Copper is an essential micronutrient required in mitochondria for energy production aerobic eukaryotes. a cofactor the enzymes cytochrome c oxidase and superoxide dismutase. Metallochaperone proteins such as Cox17, Sco1, Cox11, Ccs1 transiently bind copper intermembrane space to deliver it or However, bulk of labile pool within mitochondrial matrix. This activation cuproenzymes. Matrix bound anionic, fluorescent molecule known ligand. Using basic framework discovered Saccharomyces cerevisiae context, current state knowledge each these pools will be presented. In addition, authors highlight unexpected activities SCO cellular homeostasis mammals speculate on unresolved questions copper. Keywords: matrix copper; cytochrome oxidase; Cox17; Sco1; Cox11; mitochondria