Subthalamic infusion of an NMDA antagonist prevents basal ganglia metabolic changes and nigral degeneration in a rodent model of Parkinson's disease.
作者： J. Timothy Greenamyre , Fabio Blandini , Giuseppe Nappi
DOI: 10.1002/ANA.104
关键词:
摘要: Using permanent cannulas connected to subcutaneous pumps, we infused selective glutamate antagonists into the subthalamic nucleus of rats. Pumps were implanted immediately after intrastriatal injection 6-hydroxydopamine and delivered micro-quantities N-methyl-D-aspartate antagonist MK-801 or α-amino-3-hydroxy-5-methylisoxazole NBQX for 4 weeks. Subthalamic infusion MK-801, but not NBQX, prevented basal ganglia metabolic changes motor abnormalities caused by nigrostriatal lesion. Animals treated with also exhibited marked reduction nigral cell loss. We conclude that pharmacological modulation activity may have both symptomatic neuroprotective effects in Parkinson's disease. Ann Neurol 2001;49:525–529
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