Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis

摘要: The contribution of vitamin D insufficiency to the pathogenesis multiple sclerosis (MS) is reviewed. Among recently discovered actions D, an immunomodulatory role has been documented in experimental autoimmune encephalomyelitis and humans. This action peripheral immune system currently main known mechanism through which might influence MS, but other types could be involved within central nervous system. Furthermore, widespread temperate countries patients with MS at earliest stages disease, suggesting that deleterious effects related may exerted these patients. In fact, many genetic environmental risk factors appear interact contribute MS. genetics, several human leukocyte antigen (HLA) alleles (more particularly HLA-DRB1*1501) favour disease whereas some others protective. Some genes metabolism (e.g. CYP27B1) also play a significant role. three have identified: past Epstein–Barr virus infection, cigarette smoking. Interactions between or protective occur during mother’s pregnancy continue childhood adolescence until triggered adulthood, therefore possibly modulating throughout first decades life. clinical findings already strongly suggest status influences relapse rate radiological lesions although results adequately powered randomized trials using supplementation not yet reported. While awaiting incontrovertible results, long coming, who are should supplemented, least for their general health status, moderate doses vitamin.