Integrating Pharmacoproteomics into Early-Phase Clinical Development: State-of-the-Art, Challenges, and Recommendations

摘要: Pharmacoproteomics is the study of disease-modifying and toxicity parameters associated with therapeutic drug administration, using analysis quantitative temporal changes to specific, predetermined, select proteins, or proteome as a whole. rapidly evolving field, progress in analytic technologies enabling processing complex interactions large number unique proteins effective use clinical trials. Nevertheless, our clinicaltrials.gov PubMed shows that application proteomics early-phase development minimal limited few areas, oncology predominating. We review history, technologies, current usage, challenges, potential for future use, conclude recommendations integration pharmacoproteomic development.