Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives.
作者： Bagora Bayala , Abdou Azaque Zoure , Silvère Baron , Cyrille de Joussineau , Jacques Simpore
DOI: 10.3390/IJMS21103690
关键词:
摘要: The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in phases by targeting the levels steroid or modulating physiological activity through respective nuclear receptors when relapse. Unfortunately, at some stage, both cancers become resistant treatments that aim block receptors, estrogen (ER) androgen (AR) respectively. So far, antiestrogens antiandrogens used clinics have been designed based on structural analogies with natural hormones, 17-β estradiol dihydrotestosterone. Plants a potential source drug discovery development new compounds. this review article is highlight recent advances modulation levels, cognate cancer effects plants extracts.
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