Nonhuman Primate Models of Hematopoietic Stem Cell Transplantation

摘要: Recent advances in hematopoietic stem cell (HSC) transplantation have occurred large measure due to the development of reliable animal model systems. Clearly, most widely used models are rodent, particularly mouse. The murine system has been uniquely suited for studies defining genetics and pathogenesis graft-vs-host disease (GVHD), as well determining requirements successful engraftment histoincompatible HSC. Nevertheless, sole reliance on systems create models, which parallel human hematopoiesis effects HSC transplantation, is less than ideal a number important reasons. For instance, mice require approx one-half one full log bone marrow cells do nonhuman primates or humans order survive lethal dose myelosuppressive conditioning (1–3). This alone simple yet demonstration intrinsic differences properties primate Furthermore, there marked between with regard patterns GVHD observed following (4). example, initially tolerate fully major histocompatibility complex (MHC)-mismatched marrow, whereas mismatched even haploidentical non-T cell-depleted monkeys associated acute often (2,4).