The effects of subthalamic deep brain stimulation on mechanical and thermal thresholds in 6OHDA‐lesioned rats

摘要: Chronic pain is a major complaint for up to 85% of Parkinson's disease patients; however, it often not identified as symptom disease. Adequate treatment motor symptoms provides analgesic effects in patients but how this occurs remains unclear. Studies have shown both and 6-hydroxydopamine-lesioned rats exhibit decreased sensory thresholds. In humans, some show improvements these deficits after subthalamic deep brain stimulation, while others report no change. Differing methods testing response criteria may explain varying results. We examined effect rats. Sprague-Dawley were unilaterally implanted with stimulating electrodes the lesioned right hemisphere thresholds tested using von Frey, tail-flick hot-plate tests. Tests done during off stimulation at 50 150 Hz assess its on The animals exhibited lower mechanical (left paw, P < 0.01) thermal than shams (hot plate, 0.05). Both increased paw; (hot-plate test: Hz, 0.05, 0.01). Interestingly, Frey testing, low-frequency provided more robust improvement 6OHDA rats, others, magnitude high-frequency was greater. This study shows that improves allodynia hyperalgesia high low frequencies. Furthermore, we suggest considering when treating where predominant complaint.