摘要: The carcinoembryonic antigen (CEA) family comprises a large number of cellular surface molecules, the CEA-related cell adhesion molecules (CEACAMs), which belong to Ig superfamily. CEACAMs exhibit complex expression pattern in normal and malignant tissues. majority are that involved great variety distinct processes, for example integration responses through homo- heterophilic interaction with broad selection signal regulatory proteins, i.e., integrins or cytoskeletal components tyrosine kinases. Moreover, affects tumor growth, angiogenesis, differentiation, immune responses, they serve as receptors commensal pathogenic microbes. Recently, new insights into CEACAM structure function became available, providing further elucidation their kaleidoscopic functions.
springer.com
sci-hub.st 参考文章(284)
E.M. Kupsch, B. Knepper, T. Kuroki, I. Heuer, T.F. Meyer, Variable opacity (Opa) outer membrane proteins account for the cell tropisms displayed by Neisseria gonorrhoeae for human leukocytes and epithelial cells. The EMBO Journal. ,vol. 12, pp. 641- 650 ,(1993) , 10.1002/J.1460-2075.1993.TB05697.X
H. Hanenberg, U. Göbel, F. Grunert, S. Burdach, H. Grosse-Wilde, M. Baumann, G. Nagel, I. Quentin, S. Von Kleist, Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin. Leukemia. ,vol. 8, pp. 2127- 2133 ,(1994)
Draber P, Alpert Lc, Ilantzis C, Jothy S, Stanners Cp, Cell-surface levels of human carcinoembryonic antigen are inversely correlated with colonocyte differentiation in colon carcinogenesis. Laboratory Investigation. ,vol. 76, pp. 703- 716 ,(1997)
Song-Yang Yuan, S. Jothy, K. Shirota, Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model. American Journal of Pathology. ,vol. 143, pp. 250- 257 ,(1993)
Stephen W Barthold, A. L. Smith, S. R. Compton, The cellular and molecular pathogenesis of coronaviruses. Laboratory Animal Science. ,vol. 43, pp. 15- 28 ,(1993)
N Beauchemin, D Percy, K V Holmes, S Gagneten, C A Scanga, G S Dveksler, Attachment glycoproteins and receptor specificity of rat coronaviruses. Laboratory Animal Science. ,vol. 46, pp. 159- 166 ,(1996)
M. E. Bracke, F. M. Van Roy, M. M. Mareel, The E-cadherin/Catenin Complex in Invasion and Metastasis Attempts to Understand Metastasis Formation I. ,vol. 213, pp. 123- 161 ,(1996) , 10.1007/978-3-642-61107-0_9
AM Teixeira, J Fawcett, DL Simmons, SM Watt, The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc. Blood. ,vol. 84, pp. 211- 219 ,(1994) , 10.1182/BLOOD.V84.1.211.211
Andreas Popp, Christoph Dehio, Fritz Grunert, Thomas F. Meyer, Scott D. Gray-Owen, Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding. Cellular Microbiology. ,vol. 1, pp. 169- 181 ,(1999) , 10.1046/J.1462-5822.1999.00017.X
Phil Gold, Samuel O. Freedman, SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM Journal of Experimental Medicine. ,vol. 122, pp. 467- 481 ,(1965) , 10.1084/JEM.122.3.467