Oral delivery of the appetite suppressing peptide hPYY(3-36) through the vitamin B12 uptake pathway.

作者: Christopher H. Fazen , Debbie Valentin , Timothy J. Fairchild , Robert P. Doyle

DOI: 10.1021/JM2012547

关键词:

摘要: … Successful oral delivery of other peptides utilizing the vitamin … Herein, we present clinically relevant in vivo oral delivery of … –36) conjugates and shown oral delivery of a highly significant …

参考文章(29)
T.E. Adrian, A.P. Savage, G.R. Sagor, J.M. Allen, A.J. Bacarese-Hamilton, K. Tatemoto, J.M. Polak, S.R. Bloom, Effect of peptide YY on gastric, pancreatic, and biliary function in humans. Gastroenterology. ,vol. 89, pp. 494- 499 ,(1985) , 10.1016/0016-5085(85)90442-1
Søren L. Pedersen, Pottayil G. Sasikumar, Shekar Chelur, Birgitte Holst, Andreas Artmann, Knud J. Jensen, Niels Vrang, Peptide hormone isoforms: N-terminally branched PYY3-36 isoforms give improved lipid and fat-cell metabolism in diet-induced obese mice. Journal of Peptide Science. ,vol. 16, pp. 664- 673 ,(2010) , 10.1002/PSC.1281
G. Böttcher, J. Sjöberg, R. Ekman, R. Håkanson, F. Sundler, Peptide YY in the mammalian pancreas: immunocytochemical localization and immunochemical characterization. Regulatory Peptides. ,vol. 43, pp. 115- 130 ,(1993) , 10.1016/0167-0115(93)90146-Y
Byung-Joon Kim, Olga D. Carlson, Hyeung-Jin Jang, Dariush Elahi, Carmen Berry, Josephine M. Egan, Peptide YY Is Secreted after Oral Glucose Administration in a Gender-Specific Manner The Journal of Clinical Endocrinology and Metabolism. ,vol. 90, pp. 6665- 6671 ,(2005) , 10.1210/JC.2005-0409
Rakhi B. Shah, Fakhrul Ahsan, Mansoor A. Khan, Oral Delivery of Proteins: Progress and Prognostication Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 19, pp. 135- 170 ,(2002) , 10.1615/CRITREVTHERDRUGCARRIERSYST.V19.I2.20
Efthimia Karra, Rachel L. Batterham, The role of gut hormones in the regulation of body weight and energy homeostasis. Molecular and Cellular Endocrinology. ,vol. 316, pp. 120- 128 ,(2010) , 10.1016/J.MCE.2009.06.010
Christian L. Roth, Pablo J. Enriori, Katia Harz, Joachim Woelfle, Michael A. Cowley, Thomas Reinehr, Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss. The Journal of Clinical Endocrinology and Metabolism. ,vol. 90, pp. 6386- 6391 ,(2005) , 10.1210/JC.2005-1357
R A Pittner, C X Moore, S P Bhavsar, B R Gedulin, P A Smith, C M Jodka, D G Parkes, J R Paterniti, V P Srivastava, A A Young, Effects of PYY[3–36] in rodent models of diabetes and obesity International Journal of Obesity. ,vol. 28, pp. 963- 971 ,(2004) , 10.1038/SJ.IJO.0802696
Amanda K. Petrus, Damian G. Allis, Robert P. Smith, Timothy J. Fairchild, Robert P. Doyle, Exploring the implications of vitamin B12 conjugation to insulin on insulin receptor binding ChemMedChem. ,vol. 4, pp. 421- 426 ,(2009) , 10.1002/CMDC.200800346