Rhabdoid Tumors: Clinical Approaches and Molecular Targets for Innovative Therapy

摘要: Rhabdoid tumors are rare but highly aggressive with a predilection for infants and young children. The majority of these harbor biallelic mutations in SMARCB1/INI1/hSNF5. Rather cases other SWI/SNF core members such as BRG1 on record. have only recently been registered treated according to specifically designed treatment recommendations the framework clinical trials. Within last decade, prognosis has improved significantly at least 50% patients still relapse subsequently almost inevitably succumb their disease. This review summarizes past current approaches presents an overview rationales targeted therapy potential future trials rhabdoid tumors.