Glucocorticoids and lymphocytes. III. Effects of glucocorticoid administration on lymphocyte glucocorticoid receptors.

摘要: To determine the effects of glucocorticoid administration on number measured lymphocyte receptor sites and duration such effects, seven normal volunteers were studied. Glucocorticoid levels lymphocytes circulating in blood each volunteer determined. was then administered a regimen total four doses dexamethasone 4 mg p.o. every 6 hr. Determinations receptors performed at hr various subsequent times after end administration. When compared to baseline numbers, six showed decrease (median maximum 2,046 sites/cell). The fall occurred rapidly, reaching nadir within 30 from return more gradual, requiring 3 as long 17 days one subject. Our results suggest that order accurately interpret numbers human lymphoid cells, should not have been for wk prior determinations levels.