The Prognostic Significance of 5-Fluorouracil Induced Inflammation and Immuno-Modulation in Colorectal Cancer Patients

摘要: Aim The change in the levels of peripheral inflammatory markers together with EGFR relation to 5- fluorouracil (5-FU) therapy was evaluated for their prognostic significance colorectal cancer (CRC) patients. Patients and Methods Expression COX2, IL6, IL1β, EGFR, IL10, TNFα were determined quantitative real-time PCR (qPCR) blood 90 CRC response correlated patients' clinical features, disease-free survival (DFS), overall (OS). Results After 6 months 5-FU therapy, increased found be associated smoking, T3 or T4 tumors, performance status (PS) III, positive lymph nodes, distant metastasis, gastrointestinal (GIT) toxicity. combination COX2 interleukins a predictive equation DFS significant patients over-expression EGFR. OS rates reduced expression therapy. Significant hazard disease progression smoking (HR=1.27, P=0.004), induction IL6 (HR=1.35, P=0.001 HR=1.27, P=0.004, respectively). Moreover, TNFα, IL10 are independent factors (P=0.003, 0.003, 0.002, Conclusion effects have shown impact on treatment outcome