Bio- Fortification of Angelica gigas Nakai Nano-Powder Using Bio-Polymer by Hot Melt Extrusion to Enhance the Bioaccessibility and Functionality of Nutraceutical Compounds

摘要: Angelica gigas Nakai (AGN) is a popular traditional herbal medicine which has been used to alleviate various human diseases in Korea since ancient times. However, the low bioaccessibility of nutraceutical compounds AGN results poor water solubility, thereby limiting bioavailability. In this regard, ternary AGN–biopolymer–plasticizer composite (AGNC) was developed enhance from extrudate formulations manufactured by hot melt extrusion (HME). The AGNC prepared with (EAGN) using different hydroxypropyl methylcellulose (HPMC) biopolymers (5% w/w) viz.: hypromellose phthalate (HP), (AN), and (CN) along acetic acid (AA) (0.1 M, 20% w/v) as plasticizer. non-extrudate fresh (FAGN) powder control. physicochemical properties control were characterized differential scanning calorimetry (DSC) Fourier-transform infrared spectroscopy (FTIR). DSC analysis showed lower enthalpy (ΔH) (12.22 J/g) glass transition temperature (Tg) (41 °C) HP-AA-EAGN compared FTIR confirmed physical crosslinking between biopolymer demonstrated that some functional groups formed viz., -OH -CH2. obtained result also shows particle size reduced 341 nm, solubility increased 65.5% (1499 29.4%, respectively). total phenolic content flavonoids—including decursin (D) decursinol angelate (DA)—were significantly higher 2,2-diphenyl-1 picryl hydrazyl (DPPH) free radical scavenging capacity ferric reducing antioxidant power assay (FRAP) indicated formulation preserves greater profile than other formulations. Finally, it summarized addition acidified HP bioaccessibility, functionality, improved formulation.