Serum Hyaluronan as a Disease Marker

摘要: Hyaluronan is a connective tissue polysaccharide which has also been found in blood serum concentrations < 100 micrograms/L (average 30-40 middle-aged persons). The level regulated by the influx of from tissues via lymph and its receptor-mediated clearance liver endothelial cells. Markedly high levels are noted certain diseases, especially patients with cirrhosis, when impaired. In these cases hyaluronan can be used to follow development disease. Serum sensitive marker for impending rejection transplants. Patients rheumatoid arthritis constitute another major group increased hyaluronan, but this case varies markedly during day corresponding physical activity. There good indications that subjects excess comes joints. Under stringent sampling conditions it should possible extract interesting information on inflammatory joint process. Increased seen other diseases special interest septic sign poor prognosis. Certain tumours, notably Wilms' tumour mesothelioma, produce factors activate synthesis increase level. Rare hereditary disturbances metabolism elevated have discovered, e.g. Werner's syndrome cutaneous hyaluronanosis. Information accumulated last decade regarding made an clinical number pathological conditions.