Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene.
作者： Christian Ramos-Peñafiel , Irma Olarte-Carrillo , Rafael Cerón-Maldonado , Etta Rozen-Fuller , Juan Julio Kassack-Ipiña
DOI: 10.1186/S12967-018-1620-6
关键词:
摘要: In acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies have shown an anti-cancer effect of metformin. Therefore, the objective this study was to assess metformin on regimen in patients ALL who exhibited levels determine its impact overall survival. A total 102 were recruited; one group (n = 26) received metformin, other chemotherapy (n = 76). Measurement transcript performed using qRT-PCR prior initiation. Survival analysis Kaplan–Meier curves. The both type level response (remission or relapse) analyzed by calculating odds ratio. survival lower than those low absent (p = 0.030). individual analysis, we identified a benefit adding (p = 0.025). user group, drug acted as protective factor against therapeutic failure (odds ratio [OR] 0.07, 95% confidence interval [CI] 0.0037–1.53) early relapse (OR 0.05, CI 0.0028–1.153). combined use is effective elevated expression. Trial registration NCT 03118128:
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