Correlation between digestion of the lipid phase of smedds and release of the anti-HIV drug UC 781 and the anti-mycotic drug enilconazole from smedds.
作者： C. Goddeeris , J. Coacci , G. Van den Mooter
DOI: 10.1016/J.EJPB.2006.10.005
关键词:
摘要: The present studies were conducted primarily to compare the drug release process of anti-HIV UC781 from three different smedds digestion profile. influence every formulation component on process, measured as fatty acids, was determined. In addition, antimycotic enilconazole a investigated well in order study type incorporated oil digestion. Simulsol 1292, Tween 80, Cremophor RH40, ethanol and both drugs reduced acid release. C8, C10 C12 originating hydrolysis, able reverse inhibitory effect phospholipids medium. Similarly RH40 lost its capacities combination with Captex 200P hydrolysis. did not decrease 200P-Tween 80-ethanol mixture. significantly increased compared dissolution pure drug. profiles characterized by rapid complete followed precipitation. detect possible correlations between digestion, results those vehicle experiments. Contrary what one would assume, higher extent liberation enhance other words, does seem be driven lipid
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