Trypanosomes and the solution to a 50-year mitochondrial calcium mystery
作者： Roberto Docampo , Julius Lukeš
关键词:
摘要: The ability of mitochondria to take up Ca 2+ was discovered 50 years ago. This calcium uptake, through a mitochondrial uniporter (MCU), is important not only for the regulation cellular ATP concentration but also more complex pathways such as shaping signals and activation programmed cell death. molecular nature remained unknown decades. By comparative study protein profiles organisms lacking or possessing MCU, yeast in former case vertebrates trypanosomes latter, two groups recently found that possesses all characteristics MCU. These results add another success story already substantial contributions mammalian biochemistry.
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