Effects of cadmium on the glial architecture in lizard brain

摘要: The glial cells are positioned to be the first of brain parenchyma face molecules crossing blood-brain barrier with a relevant neuroprotective role from cytotoxic action heavy metals on nervous system. Cadmium is highly toxic metal and its levels in environment increasing due industrial activities. This element can pass have neurotoxic activity. For this reason we studied effects cadmium architecture lizard Podarcis siculus, significant bioindicator chemical exposure persistence variety habitats. study was performed two groups lizards. group P. siculus exposed an acute treatment by single i.p. injection (2 mg/kg-BW) CdCl2 sacrificed after 2, 7 16 days. second one used as control. histology Hematoxylin/Eosin Cresyl/Violet stains while structures were analyzed immunodetection fibrillary acidic protein (GFAP), most widely accepted marker for astroglial cells. Evident morphological alterations observed at days injection, when revealed also decrease GFAP-immunopositive particular rhombencephalic ventricle, telencephalon optic tectum. These results show that lizards provokes cellular but decrement expression GFAP possible consequent damage functions.