Piezoresistive Cantilever-based Force-Clamp System for the Study of Mechanotransduction in C. Elegans

作者: S.-J. Park , B. Petzold , M.B. Goodman , B.L. Pruitt

DOI: 10.1109/MEMSYS.2009.4805350

关键词:

摘要: Understanding how the mechanoreceptor neurons of Caenorhabditis elegans mediate mechanotransduction can unravel touch works, but new tools are required to quantitatively analyze relationship between mechanical loading and physiological response. Here we present a piezoresistive cantilever-based force clamp system that apply user-defined profiles C. elegans. We novel MEMS force-clamp demonstrate cantilever with low 1/f noise, noise floor high resolution suitable for these measurements. Initial studies enabled by also discussed.

参考文章(8)
Ian D. Hope, C. elegans : a practical approach Oxford University Press (OUP). ,(1999)
J. R. Mallon, A. J. Rastegar, A. A. Barlian, M. T. Meyer, T. H. Fung, B. L. Pruitt, Low 1∕f noise, full bridge, microcantilever with longitudinal and transverse piezoresistors Applied Physics Letters. ,vol. 92, pp. 033508- ,(2008) , 10.1063/1.2825466
S.-J. Park, M. B. Goodman, B. L. Pruitt, Analysis of nematode mechanics by piezoresistive displacement clamp Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 17376- 17381 ,(2007) , 10.1073/PNAS.0702138104
Beth L. Pruitt, Thomas W. Kenny, Piezoresistive cantilevers and measurement system for characterizing low force electrical contacts Sensors and Actuators A-physical. ,vol. 104, pp. 68- 77 ,(2003) , 10.1016/S0924-4247(02)00485-5
R.S. Johansson, Å.B. Vallbo, G. Westling, Thresholds of mechanosensitive afferents in the human hand as measured with von Frey hairs Brain Research. ,vol. 184, pp. 343- 351 ,(1980) , 10.1016/0006-8993(80)90803-3
Robert O'Hagan, Martin Chalfie, Miriam B Goodman, The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nature Neuroscience. ,vol. 8, pp. 43- 50 ,(2005) , 10.1038/NN1362
Miriam B Goodman, Erich M Schwarz, None, Transducing Touch in Caenorhabditis elegans Annual Review of Physiology. ,vol. 65, pp. 429- 452 ,(2003) , 10.1146/ANNUREV.PHYSIOL.65.092101.142659
Sung-Jin Park, Joseph C. Doll, Ali J. Rastegar, Beth L. Pruitt, Piezoresistive Cantilever Performance—Part II: Optimization IEEE\/ASME Journal of Microelectromechanical Systems. ,vol. 19, pp. 149- 161 ,(2010) , 10.1109/JMEMS.2009.2036582