Genotypic and phenotypic resistance testing of HIV-1 in routine clinical care.

摘要: Data on genotypic and phenotypic resistance testing of HIV-1 in the routine clinical setting are lacking. In a retrospective single-center study, all patients (n=102) for whom typing (GRT) (PRT) were performed during calendar year 2002 examined. GRT PRT results concordant 79% drugs, being highest nevirapine (92%) lowest didanosine (57%). Concordance protease inhibitors was lopinavir (78%) indinavir (88%). Discordant lamivudine observed 16% patients; 90% these corresponded to high-level by susceptibility GRT. Overall, HIV loads lower CD4+ cell counts higher after therapy following testing, but significant association with number active drugs as predicted or could not be identified. subgroup 43 virological failure under antiretroviral sufficient follow-up data, significantly 3 6 months. More <400/ml had 2 more according (21/29 [75%]) than ([15/29 [52%]; p=0.109. This also found <50/ml (PRT 16/22 [72%], 10/22 [42%]; p=0.103), although differences statistically significant. There no discernable difference between clinic-based population, numbers tests draw definitive conclusions.