Narrative Review: Evolving Concepts in Potassium Homeostasis and Hypokalemia

摘要: Humans are intermittently exposed to large variations in potassium intake, which range from periods of fasting ingestion potassium-rich meals. These fluctuations would abruptly alter plasma concentration if not for rapid mechanisms, primarily skeletal muscle and the liver, that buffer changes by means transcellular redistribution feedback control renal excretion. However, buffers have capacity limits, even robust mechanisms require perturbation occur before can initiate corrective action. In contrast, feedforward sense effect disturbances on system's homeostasis. This review highlights recent experimental insights into participation New data make clear homeostatic responses activate when decreased intake is sensed, still within normal frank hypokalemia ensues, addition classic activation conservation decreases. Given clinical importance dyskalemias patients, these novel paradigms invite renewed inquiry this important area.