Reducing Errors in Identification of von Willebrand Disease: The Experience of the Royal College of Pathologists of Australasia Quality Assurance Program

摘要: Regular multilaboratory surveys of laboratories derived primarily from Australia, New Zealand, and Southeast Asia have been conducted during the last 8 years to evaluate testing proficiency in diagnosis von Willebrand disease (vWD). We summarize update findings these with a particular emphasis on diagnostic errors error rates associated tests or test panel limitations. A total 43 plasma samples dispatched survey participants. These included 13 normal samples, five type 1 vWD eight 2 (three 2A, three 2B, one 2M, 2N), four 3 samples. In addition numerical results, participant (currently, n = 49) were asked provide interpretations regarding whether not was suggested, if so, probable subtype. Although usually provided correct interpretative responses, occurred substantial number cases. On average, misidentified as 13.3% cases, performing factor (vWF):ristocetin cofactor activity (RCo) without vWF:collagen-binding (CB) seven times more likely make such an compared those vWF:CB. Similarly, average 20.1% vWF:RCo vWF:CB Finally, 6.7% conclude that although are generally proficient for vWD, do occur substantially reduced when panels comprehensive include