Synthesis and anticancer activity of 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones
作者： Weerachai Phutdhawong , Gedsirin Eksinitkun , Wanwikar Ruensumran , Thongchai Taechowisan , Waya S. Phutdhawong
DOI: 10.1007/S12272-012-0502-3
关键词:
摘要: A series of naphthoquinones fused benzazepines, 5,6,8,13-tetrahydro-7H-naphtho[2,3-a][3]-benzazepine-8,13-diones, were synthesized and evaluated for their anticancer activity against four cell lines; human breast carcinoma line, cervix hepatocellular line keratinocyte line. The results showed that 5,6,8,13-tetrahydro-2,3,4,9-tetramethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4g 5,6,8,13-tetrahydro-2,3,9-trimethoxy-7H-naphtho[2,3-a][3]benzazepine-8,13-dione 4h have significant cytotoxicity a with IC50 = 3.5 μg/mL 3.0 μg/mL, respectively.
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