Interleukin-13 induces expression and release of interleukin-1 decoy receptor in human polymorphonuclear cells.

摘要: The aim of this study was to examine whether interleukin-13 (IL-13), a cytokine with anti-inflammatory activities, affected expression interleukin-1 (IL-1) receptors (R) in human polymorphonuclear cells (PMN). Treatment IL-13 augmented both type I and II (decoy) R transcripts, the latter being by far most represented. transcriptional inhibitor actinomycin D blocked induction IL-1 mRNAs IL-13. Nuclear run-off experiments demonstrated an rate decoy IL-13-treated B lymphoblastoid cells. protein synthesis cycloheximide but superinduced expression. binding radiolabeled beta on PMN surface increased number no change Kd values. induced release IL-1-binding identified as soluble version R. These results show that is important target for R, concert inhibition synthesis, may represent mechanism which blocks IL-1, central mediator inflammatory reactions.