Selective immunotoxic lesions of basal forebrain cholinergic neurons: twenty years of research and new directions.

摘要: The advent of the selective cholinergic toxin, 192 IgG-saporin, dramatically shaped subsequent research on role basal forebrain in learning and memory. In particular, several articles (including authors' 1995 Behavioral Neuroscience paper; M. G. Baxter, D. J. Bucci, L. K., Gorman, R. Wiley, & Gallagher, 1995) revealed that removal neurons had surprisingly little effect spatial Here, as part series commemorating 30th anniversary Neuroscience, we describe how our earlier findings prompted a reconsideration contribution to cognitive function also led new directions, including renewed interest GABA-ergic contributions neurocognitive development. authors successful use IgG-saporin development popularity wide range neurotoxic agents. Finally, they consider utility permanent lesion approach wake transgenic optogenetic methods.