Exacerbated phagocytosis and sleep apnea syndrome

摘要: Introduction The Obstructive Sleep Apnea Syndrome (OSAS) intermittent hypoxia and sleep fragmentation contributes to alter architecture, damaging the cellular immune mechanism regulated by wake cycle stimulating production of pro inflammatory cytokines reactive oxygen species phagocytes. Thus, patients with OSAS have a non-functional pro-inflammatory response. So, it is important evaluate phagocytic function polymorphonuclear cells its correlation increased susceptibility acute infections. Materials methods 34 volunteers divided in two groups: 15 polysomnographic diagnosis moderate severe (Apnea Hypopnea Index  >  15 Arousal  20) 13 excluded absence snoring, daytime sleepness complaints disorder. exclusion criteria were conditions that change differential diseases. phagocytosis test subsequent blind analysis has determined proportion engaged (% F), average yeasts phagocytosed (ML) index (PI). Results was individuals sensitized medium yeast concentration 20 per phagocyte macrophages (M) neutrophils (N): % [N, S - 91.0 (77.6/94.9) x-C 73.6 (52.4/91), p = 0.03*] [M: 68.8 (61.3/81.4) x C 46.9 (34.9/63.7), p = 0.003] [N: 3.4 ( 2.7/3.8) 2.7 (2.4/3.2), p = 0.05*] 2.624 ±  0.1016) -2236 0.1763), p =  0.06] [ N: S-313.9 30.58 C-221.4 33.11, p = 0.053] 188.4 (  13.73) C-114.9  17.68), p = 0.003]. There no statistical difference these parameters non-sensitized or 5 phagocyte. Conclusion clinical predisposing factors for OSAS. Individuals obtained higher rates through more stimuli, which correlates hyperactivation other functions already described OSA. These findings not found environments little stimulation, showing dependence triggering factor, could correspond an infection vivo. This elucidated confirms presence hyperstimulation OSAS, contribute elucidation pathophysiology possible complications disease.