Neural signaling in the spleen controls B-cell responses to blood-borne antigen.

摘要: Entry of blood-borne pathogens into the spleen elicits a series changes in cellular architecture that culminates systemic release protective antibodies. Despite an abundance work has characterized these processes, regulatory mechanisms coordinate cell trafficking and antibody production are still poorly understood. Here, marginal zone (MZ) B cells responding to streptococcus blood were observed migrate along splenic nerves, arriving at red pulp venous sinuses where they become antibody-secreting cells. Electrical stimulation vagus nerve, which turn regulates arrested B-cell migration decreased secretion. Thus, neural circuits regulate first wave following exposure antigen.