Hypercapnia induces a concentration-dependent increase in gastric mucosal oxygenation in dogs.

摘要: To clarify the effects of hypercapnia (increased PaCO2) on gastric mucosal oxygenation during anaesthesia in dogs. Prospective, controlled animal study. Experimental research laboratory an university hospital. Six chronically instrumented Dogs were anaesthetized (sevoflurane 1.5 MAC), mechanically ventilated (etCO2 = 35 mmHg) and randomly assigned to following protocols: a first series, ventilation was adjusted increase etCO2 45, 55, 65 70 mmHg. In second animals achieve 70 mmHg etCO2, which maintained for 120 min test if are transient or prolonged similar time course both protocols. Gastric (μHbO2) assessed continuously by tissue reflectance spectrophotometry. Mean arterial blood pressure (MAP) cardiac output (CO) measured. Blood sampled gas analysis lactate concentration. Hypercapnia increased concentration dependently from 48 ± 6% (35 mmHg etCO2) 51 ± 4, 54 ± 5, 56 ± 5 59 ± 3% (etCO2 70 mmHg, respectively). This reflected changes CO (68 ± 16, 74 ± 16, 82 ± 12, 91 ± 11 97 ± 16 ml kg−1 min−1, respectively) systemic oxygen delivery (10 ± 2, 11 ± 3, 13 ± 2, 14 ± 2 14 ± 2 ml kg−1 min−1, These persisted 2 h (μHbO2 53 ± 6 vs. 64 ± 4%, 73 ± 16 92 ± 15 ml kg−1 min−1, DO2 12 ± 4 14 ± 3 ml kg−1 min−1, 35 regional oxygenation. If this experimental finding may be transferred clinical setting, permissive might used augment splanchnic region, e.g. gastrointestinal mucosa.