Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata

摘要: Three lignans and four flavonoids were isolated characterized from Larrea tridentata compounds tested against 16 bacterial species/strains. Results showed that: dihydroguaiaretic acid (1) had activity towards methicillin resistant (MR) Staphylococcus aureus (minimum inhibitory concentration (MIC) 50 µg/mL) multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (MIC 12.5–50 µg/mL); 4-epi-larreatricin (2) was active Enterobacter cloacae 12.5 µg/mL), as well sensitive MDR M. 25 µg/mL). 3′-Demethoxy-6-O-demethylisoguaiacin (3) displayed S. 25 µg/mL), Enterococcus faecalis Escherichia coli 50 µg/mL), E. 12.5 µg/mL) 12.5 µg/mL). 5,4′-Dihydroxy-3,7,8,3′-tetramethoxyflavone (4) 5,4′-dihydroxy-3,7,8-trimethoxyflavone (5) having MIC values 25 25–50 µg/mL, respectively, while 5,4′-dihydroxy-7-methoxyflavone (6) 50 µg/mL). We concluded that lignan 3 is the main compound responsible for antibacterial L. tridentata. Lignans 1 2 flavonoid 6 contribute with some degree activity. On other hand, 1, 2, 3, 4 5 contributed to antimycobacterial found in Copyright © 2012 John Wiley & Sons, Ltd.