Micromachined flow cytometers with embedded etched optic fibers for optical detection
作者： Che-Hsin Lin , Gwo-Bin Lee , None
DOI: 10.1088/0960-1317/13/3/315
关键词:
摘要: This paper presents a device that integrates micromachined flow cytometer with two embedded etched optic fibers in order to carry out on-line detection of particles and cells. A simple reliable fabrication process is used fabricate the on soda-lime glass substrates. It shown experimentally particles/cells can be squeezed hydrodynamically into narrow stream by neighboring sheath flows such they individually through region. The resulting scattered light then detected downstream. proposed approach has advantage counted without need for fluorescent labeling or delicate optical alignment procedures. current study confirms success microchip counting polystyrene beads human blood results also indicate intensity proportional size particles/cells, which suggests may offer potential distinguish between different sizes.
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