Role of sulfate conjugation of catecholamines in blood pressure regulation.

摘要: Catecholamine sulfates were found to be inactive at vascular receptor sites. Only one nonvascular site important for blood pressure (BP) regulation was dopamine-3-O-sulfate an inhibitory modulator of the adrenocortical secretion aldosterone in vitro. However, sulfation catecholamines (CA) does play role BP regulation, as shown by following observations: Sulfoconjugated CA with a long half-life are sometimes better markers release than free CA, which have short half-lives. This is particularly true dopamine (DA) sulfate because DA, being rapidly sulfoconjugated, usually undetectable. led recognition previously unsuspected DA paroxysmal hypertension and orthostatic hypotension. Measurements reveal potentially storage functions sulfoconjugation that can inactivate excessive circulating so mitigate their cardiovascular impact while building up pool conjugated CA. The possibility generated from this through deconjugation whenever need them arises should further investigated. Reproducible individual differences velocity infused detected, suggests genetic control certain components sulfoconjugating process. These probably modulate action some drugs similar structure also undergo sulfoconjugation.