Placental pathology in pregnancies complicated by fetal growth restriction: recurrence vs. new onset

摘要: Objective In an attempt to shed new light on the pathogenesis of fetal growth restriction (FGR), we aimed study pregnancy characteristics, neonatal outcomes, and placental histopathological lesions FGR pregnancies in two different subgroups: when developed after appropriate for gestational age (AGA) previous with FGR. Study design Pregnancy reports all singleton complicated by (defined as actual birthweight below 10th percentile according local nomograms) between 2008 2018 were reviewed. Included only cases delivery. Maternal background, histopathology compared that occurred (recurrent group) AGA (FGR group). Placental classified current "Amsterdam" criteria. Continuous variables using Student's t test or Mann-Whitney appropriate. Categorical Chi-square Fisher's exact Results A total 334 a delivery included study. Of them, 111 constituted recurrent group 223 group. The was characterized higher rates maternal diabetes during hypertensive diseases (9% versus 2.7%, p = 0.01 19.8% 11.6%, 0.04). rate vascular malperfusion (FVM) (29.6% 18.0%, 0.02), lower mean (1842 ± 424.9 1977.4 412.2, 0.005), Conclusion Recurrent associated background morbidities which represents chronic repeated insult, while "new" (those followed pregnancy) FVM probably represent "accident" placentation. These findings may suggest mechanisms dysfunction exist subgroups