Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications

摘要: Abstract Exposure of cells to agonists receptors linked G proteins can result in downregulation cellular levels or redistribution from membranes the cytosol. Agonist-induced reductions protein have been observed for members each s , i and q families proteins, are likely be dependent upon level receptor expression, generally restricted protein(s) with which interacts. The mechanisms responsible, reviewed here by Graeme Milligan vary cell type include both second messenger-dependent -independent enhanced degradation. reduction provide one mechanism development sustained heter-ologous desensitization.