Cytochrome p450 part 2: what nurses need to know about the cytochrome p450 family systems
作者： Stephen D. Krau
DOI: 10.1016/J.CNUR.2013.09.003
关键词:
摘要: To provide the best patient care related to medication administration and prescription, an understanding of specific enzymes is essential. Enzymes affect metabolizing most medications that nurses administer nurse practitioners physicians prescribe on a regular basis. More specifically, important p450 in drug metabolism are cytochrome (CYP) 1A2, CYP2C family, CYP2D6, CYP3A4. In addition, instrumental body's reaction environmental factors, some which carcinogens.
elsevier.com
sci-hub.se 参考文章(58)
Cytochromes P450 : role in the metabolism and toxicity of drugs and other xenobiotics Royal Society of Chemistry. ,(2008) , 10.1039/9781847558428
Vincent Haufroid, Danuta Ligocka, Martin Buysschaert, Yves Horsmans, Dominique Lison, Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes European Journal of Clinical Pharmacology. ,vol. 59, pp. 29- 33 ,(2003) , 10.1007/S00228-003-0566-6
Zaiqi Wang, Stephen D. Hall, Juan F. Maya, Lang Li, Ali Asghar, J. C. Gorski, Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. British Journal of Clinical Pharmacology. ,vol. 55, pp. 77- 85 ,(2003) , 10.1046/J.1365-2125.2003.01731.X
M Ingelman-Sundberg, L Bertilsson, I Johansson, I Persson, F Rodrigues, E Aklillu, Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles. Journal of Pharmacology and Experimental Therapeutics. ,vol. 278, pp. 441- 446 ,(1996)
Ming-Derg Lai, Su-Lan Wang, Jin-ding Huang, G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metabolism and Disposition. ,vol. 27, pp. 385- 388 ,(1999)
P. B. Watkins, S. A. Wrighton, P. Maurel, E. G. Schuetz, G. Mendez-Picon, G. A. Parker, P. S. Guzelian, Identification of an inducible form of cytochrome P-450 in human liver Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 6310- 6314 ,(1985) , 10.1073/PNAS.82.18.6310
Anthe S. Zandvliet, Alwin D.R. Huitema, William Copalu, Yasuhide Yamada, Tomohide Tamura, Jos H. Beijnen, Jan H.M. Schellens, CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity. Clinical Cancer Research. ,vol. 13, pp. 2970- 2976 ,(2007) , 10.1158/1078-0432.CCR-06-2978
John P. Plastaras, F. Peter Guengerich, Daniel W. Nebert, Lawrence J. Marnett, Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. Journal of Biological Chemistry. ,vol. 275, pp. 11784- 11790 ,(2000) , 10.1074/JBC.275.16.11784
Shu-Feng Zhou, Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clinical Pharmacokinectics. ,vol. 48, pp. 689- 723 ,(2009) , 10.2165/11318030-000000000-00000
Mellar P. Davis, Jade Homsi, The importance of cytochrome p450 monooxygenase CYP2D6 in palliative medicine Supportive Care in Cancer. ,vol. 9, pp. 442- 451 ,(2001) , 10.1007/S005200000222