Activation of nociceptin/orphanin FQ‐NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D1 receptor signaling in rat nucleus accumbens and dorsal striatum
作者： Maria C. Olianas , Simona Dedoni , Marianna Boi , Pierluigi Onali
DOI: 10.1111/J.1471-4159.2008.05629.X
关键词:
摘要: Nociceptin/orphanin FQ (N/OFQ) has been reported to inhibit dopamine (DA) release in basal ganglia mainly by acting on NOP receptors substantia nigra and ventral tegmental area. We investigated whether N/OFQ could affect DA transmission at either nerve endings or DA-targeted post-synaptic neurons. In synaptosomes of rat nucleus accumbens striatum inhibited synthesis tyrosine hydroxylase (TH) phosphorylation Ser40 via coupled inhibition the cAMP/protein kinase A pathway. Immunofluorescence studies showed that preferentially phospho-Ser40-TH shell this subregion partly colocalized with TH D1 receptor positive structures. receptor-stimulated cAMP formation, but failed adenosine A2A D2 regulation cAMP. slices, D1-induced NMDA α-amino-3-hydroxy-5-methylisoxazole-4-propionate glutamate receptors, whereas primary cultures accumbal cells, which were found coexpress curtailed receptor-induced cAMP-response element-binding protein phosphorylation. Thus, exerts an inhibitory constraint pre-synaptic inhibiting selectively down-regulating signaling.
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