Effect of tidal volume and nebuliser position on aerosol delivery during neonate ventilation

摘要: Introduction: Concurrent delivery of aerosolised therapeutics is commonly prescribed during neonatal mechanical ventilation. Neonates present unique challenges for aerosol therapy due to their low tidal volumes, rapid breathing and small airways interfaces. The objective this study was evaluate the effect volume nebuliser position on simulated Methods: A ventilator (Maquet Servo I, Getinge, Germany) (Vt 5mL 10mL, 60BPM, I:E 1:2) in combination with a 2.5mm endotracheal tube (ETT) humidified circuit used. 2000µg Salbutamol nebulised using Aerogen Solo (Aerogen, Ireland) lung dose assessed across four positions within circuit. Lung quantified by UV spectroscopy at 276 nm, following elution drug captured distal end tube. Results Table 1. Mean ± standard deviation values (µg). Conclusions: Increasing associated greater dose, exception placing before Wye. However, difference only observed be statistically significant when placed wet side humidifier. Consistent previous reports, between wye ETT shown have most ventilation, both volumes.