Expression of transferrin mRNA in rat oligodendrocytes is iron-independent and changes with increasing age

摘要: As transferrin in the brain may originate principally from synthesis by three different cell types, i.e. hepatocytes, oligodendrocytes and choroid plexus, this study employed a morphological analysis to specifically address oligodendrocytic expression of mRNA young (P17) adult (P50) rats. In spite lowering concentration iron approximately 22% deficient rats was not affected when measured quantitative densitometry. rats, baseline higher than animals, but did change reduction 19%. Brain were unaltered overloaded compared age-matched controls. lower rat, constituents blood have relatively during adulthood, it seems unlikely that blood-borne factors such as transition metals act inducers gene oligodendrocytes. Instead, constitutive at later ages, blood-brain barrier segregates other body parts, indicate molecules released interior are responsible for regulating transcription gene.