Roles of gastro-oesophageal afferents in the mechanisms and symptoms of reflux disease.

摘要: Oesophageal pain is one of the most common reasons for physician consultation and/or seeking medication. It often caused by acid reflux from stomach, but can also result contractions oesophageal muscle. Different forms are evoked acid, including heartburn and non-cardiac chest pain, basic mechanisms pathways which these generated remain to be elucidated. Both vagal spinal afferent implicated research. The sensitivity fibres within may become altered after acid-induced inflammation damage, severity symptoms in humans does not necessarily correlate with degree inflammation. Gastro-oesophageal disease (GORD) transient relaxations lower sphincter, triggered activation gastric mechanoreceptors. Vagal afferents therefore an emerging therapeutic target GORD. Pain absence excess remains a major challenge treatment.