Pushing the Functionality of Diamond Nanoparticles to New Horizons: Orthogonally Functionalized Nanodiamond Using Click Chemistry

摘要: Click chemistry is one of the most versatile means for efficient grafting larger units such as fluorescence labels or biomolecules onto surface nanoparticles. Here, a first study on applicability different strategies copper-catalyzed azide–alkyne coupling diamond nanoparticles and organic moieties reported. Both thermally annealed nanodiamond mechanically pretreated origin can be modified with carrying either azide alkyne groups. Several have been efficiently “clicked” these particles. The method then applied bifunctional modification leading to material exhibiting carboxylic groups at same time. These addressed by orthogonal linkers. A model two distinct fluorescent dyes produced this way shows characteristic luminescence both dyes. findings open application multifunctional labels, drug delivery vehicles, targeting agents in biomedical applications.