Chiral liquid chromatography: past and present

摘要: Around 1812, the French physicist Biot discovered existence of optical activity in crystals α-quartz(O’Loane, 1980). Credit for first resolution enantiomers from a racemate goes to Louis Pasteur who, 1848, separated manually non-identical sodium ammonium tartrate (Pasteur, 1848). In 1874, Le Bel and Van’t Hoff independently proposed ‘asymmetric carbon atom’ account chirality organic compounds. (1874) favoured square pyramidal arrangement substituents around an apical atom whereas correctly postulated tetrahedral central atom. Not surprisingly, early attempts obtain racemates utilized readily-available, naturally-occurring chiral materials such as wool, silk, quartz polysaccharides starch or cellulose. At turn century, Wilstatter (1904) that it should be possible resolve racemic dyes solution by enantioselective adsorption onto wool.