Renal and vascular activity of prolactin preparations. Contamination of prolactin preparations with ADH and implications on renal and vascular prolactin research.

摘要: Prolactin, as a “broad spectrum hormone”, has been described to exert also vascular and renal actions in laboratory animals humans. However, prolactin preparations of various species are contaminated with neurohypophysial hormones (ADH, oxytocin) which possess activities. Antisera against ADH, oxytocin rather specific inactivators the biologic activity respective hormone; oxytocinasevasopressinase system pregnancy plasma destroys ADH oxytocin. Incubation-identification procedures antisera revealed that changes blood pressure, urine flow urinary osmolarity cannot be ascribed per se but impurity preparations. Furthermore, recent metabolic studies normally hydrated, overhydrated dehydrated humans have shown does not affect water electrolyte excretion. Thus, earlier reports on should viewed great caution. Elimination hormone impurities by incubation either or provides techniques for better assessment real effects molecule.