Activation of Immune-Mediated Tumor Cell Death by Chemotherapy

摘要: Like pathogens, tumor cells express a range of antigens that can be recognized by the immune system and are therefore susceptible to immune-mediated death. It is widely plays significant role in preventing cancer development through elimination malignant pre-malignant cells, controlling growth, once this protective mechanism has failed. The capacity contribute success anti-cancer therapy, however, more recent concept. Originally assumed have detrimental effect on anti-tumor immunity due its indiscriminate targeting proliferating including lymphocytes, it now emerged chemotherapy enhance responses altering level context antigen presentation effectors immunological milieu, creating favorable environment for generation immunity. Activation cell death opens door possibility novel treatment strategies combining standard with immunotherapy agents aimed at enhancing such responses. Preclinical studies early phase trials combination chemoimmunotherapy produced promising results. However, becoming clear synergy dependent not only drugs selected, but also intrinsic properties host tumor. Development regimens will require careful design an individualized approach.