Bioorthogonal Reaction for Fluorine-18 Labeling
作者： Dong Wook Kim
DOI: 10.1007/978-3-319-67720-0_14
关键词:
摘要: Specific molecular imaging probes including radiopharmaceuticals labeled with positron-emitters, such as fluorine-18 (18F, t1/2 = 109.8 min), need to expand their applications of positron emission tomography (PET) study. In recent years, bioorthogonal chemistry inverse electron-demand Diels-Alder cycloaddition reactions and strain-promoted alkyne azide (SPAAC) has been regarded alternative ligation bioactive molecules radiolabeled building blocks. this chapter, I will introduce an overview emerging synthetic strategies based on the catalyst-free SPAAC conjugation reaction using tetrazine/trans-cyclooctene (TCO) derivatives under physiologically-friendly conditions. also that pretargeting method by for tracking mesoporous silica nanoparticles (MSNs) in vivo system. This SPAAC-based protocol allow 18F a short half-life be used labeling MSNs obtain PET images.
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