Role of extracellular matrix remodelling in adipose tissue pathophysiology. Relevance in the development of obesity

摘要: Adipose tissue responds dynamically to alterations in nutrient excess through adipocyte hypertrophy and hyperplasia, followed by increased angiogenesis, immune cell infiltration, extracellular matrix (ECM) overproduction, thus, production of proinflammatory adipokines during the progression chronic inflammation. remodelling is an ongoing process that pathologically accelerated obese state large part mediated ECM proteins proteases. The subject major modifications adipocytes other types are infiltrated adipose tissue, such as macrophages vascular cells. In obesity, unusual expression components fragments derived from tissue-remodelling processes can influence recruitment activation, actively contributing turnover requires a tightly regulated balance between synthesis their proteolysis, mainly fibrinolytic systems metalloproteases (MMPs). this review, we discuss key cellular steps lead main molecular mechanisms mediators process. We highlight importance hypoxia angiogenesis process, well cross-talk adipocytes, components.