Ranitidine Versus Colloidal Bismuth Subcitrate in Combination with Amoxicillin and Metronidazole for Eradicating Helicobacter pylori in Patients with Duodenal Ulcer

摘要: One hundred twenty-two patients were randomly assigned to three groups of treatment (A, B, and C), with (I) ranitidine (300 mg q.d. for 6 weeks), (2) weeks) amoxicillin (500 t.i.d.) metronidazole b.i.d.) the first 12 days, or (3) colloidal bismuth subcitrate (120 q.i.d. (at same dosages as in latter group). Six weeks after beginning treatment, an endoscopy showed that ulcers had healed 49 52 (94.2%) from whom Helicobacter pylori been eradicated 59 70 (84.3%) it not (NS). The rates H. eradication A, C zero, 47.5%, 86.8%, respectively. At 6, 12, 18 months, was repeated monitoring ulcer recurrence status. Reinfection at months 42.1% 15.1% B C, respectively (P <.05). recurred 82.9% (63) 76 noneradicated infection, vs. 5.7% 35 without infection <.001). We conclude is more effective than when given plus duodenal ulcer, both early reinfection are diminished.