An attachable silver-impregnated cuff for prevention of infection with central venous catheters: A prospective randomized multicenter trial

摘要: Abstract Purpose: Percutaneously inserted central venous catheters are widely used. Catheter-related bacteremia or fungemia is the most frequent serious complication of these catheters. In an attempt to reduce frequency such infections, a subcutaneous cuff constructed biodegradable collagen matrix impregnated with bactericidal silver was developed. Our goal assess, in multicenter clinical trial, effectiveness this preventing catheter-related infection. MATERIALS AND METHODS: Central needed for fluid drug therapy, hemodynamic monitoring, hyperalimentation patients three centers were randomly assigned be without cuff. Patients and two groups comparable terms risk factors predisposing infection, including colonization skin about insertion site. Results: The results 234 into new site showed that threefold less likely colonized on removal (more than 15 colony-forming units) control (28.9 percent versus 9.1 percent, p=0.002) nearly fourfold produce (3.7 1.0 percent). Adverse effects from not seen. did confer protection, however, against infection over guidewire old sites. Most infections identified study, four six bacteremias, appear have been caused by microorganisms colonizing site, affirming pathogenetic basis benefit seen trial; may derived contamination catheter hub. Conclusion: This novel, silver-impregnated, attachable can substantially incidence percutaneously catheters, extend time left place safely, prove cost-beneficial.