Plaque Radiotherapy for Uveal MelanomaLong-term Visual Outcome in 1106 Consecutive Patients

摘要: Objective To identify clinical predictive factors for visual outcome in a large series of patients who underwent plaque radiotherapy uveal melanoma. Design Clinical factors, including patient data, tumor features, and radiation variables, were analyzed their impact on acuity using Cox proportional hazards regression models. Participants Patients with melanoma initial 20/100 or better the affected eye treated between July 1976 June 1992. Main Outcome Measures Two end points used to evaluate posttreatment acuity: (1) final (good [20/20-20/100] vs poor [20/200 no light perception]) (2) loss (minimal [ Results Of 1300 consecutive by radiotherapy, 1106 had at time treatment. In this group, was found 34% 5 years 68% 10 follow-up. From multivariable analysis, that best predicted increasing thickness, proximity foveola less than mm, notched shape, recurrence, age 60 older, subretinal fluid, cobalt isotope, anterior margin posterior equator, worse acuity. Moderate Snellen lines more 33% 69% moderate included acuity, diabetes mellitus hypertension. When analyzing regard ultimate 20/200 24% small (≤3.0 mm), 30% medium (3.1-8.0 64% (>8.0 mm). visually important structures, tumors mm from optic disc demonstrated 35% years, whereas those showed 25% years. Conclusions Ultimate after depends many general health, location size, radioactive control. At years' follow-up, demonstrate Visual is most effectively preserved eyes outside radius foveola.