Additional genetic risk factors for venous thromboembolism in carriers of the factor V Leiden mutation.

摘要: Only a minority of subjects with factor V (FV) Leiden mutation develop venous thromboembolism (VTE), suggesting that additional genetic risk factors may be present in symptomatic carriers. We screened 157 unrelated carriers the FV first episode VTE and 291 asymptomatic for presence two frequent mutations, i.e. G20210A prothrombin gene C677T methylenetetrahydrofolate reductase gene. Carriers other inherited or acquired thrombophilia-associated abnormalities were excluded from analysis. Heterozygotes more prevalent among than (10.8% v 2.7%, P < 0.0001); homozygotes also (21.6% 14.4%, P = 0.05). Factor who had during oral contraceptive intake frequently (14.3%, P = 0.03). These results further support idea interaction circumstantial factors, an accurate search such is required to identify at risk.