Quantity and Avidity of Pneumococcal Antibodies Before and Up to Five Years After Pneumococcal Vaccination of Elderly Persons

摘要: It is not known how long vaccine-induced type-specific pneumococcal antibodies persist or whether age-related changes in their avidity occur; we therefore administered vaccine to 15 elderly persons aged 60-67 years determine the level and of before vaccination again 4 weeks 5 later. Antibody levels were significantly higher after than 67% these subjects (P < .01). On basis guidelines established for revaccination, found that 60% required revaccination primary immunization antibody status remaining 40% would need be determined some No significant differences IgG detected connection with type pneumococcus, vaccinee (i.e., sera assayed later), age vaccinee.