Maternal immune activation and abnormal brain development across CNS disorders

作者: Irene Knuesel , Laurie Chicha , Markus Britschgi , Scott A. Schobel , Michael Bodmer

DOI: 10.1038/NRNEUROL.2014.187

关键词:

摘要: Activation of the immune system during pregnancy can have varied effects on fetal development, and converging evidence highlights maternal activation as a risk factor for multiple neurological conditions. In this Review, Knuesel colleagues discuss involvement in schizophrenia, austim spectrum disorders, epilepsy other disorders. The authors then how preclinical data indicate possible link between prenatal exposure to infection susceptibility neurodegenerative disease, they go identify fertile ground further translational research.

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